UnclearInsufficient evidencePaper 57

Cellular signaling pathways in the nervous system activated by various mechanical and

Keywords

#mechanotransduction #nervous system #mechanical stimuli #electromagnetic stimulation #ultrasound #neurorehabilitation #cellular signaling pathways #mechanosensors

This review summarizes cellular signaling pathways in the mammalian nervous system reported to be activated by various mechanical and electromagnetic stimuli, and briefly discusses potential cellular mechanosensors involved.

Study snapshot

PublicationFrontiers in Molecular Neuroscience · 2024

Study typereview

Reported directionUnclear

Evidence ratingInsufficient

Abstract

Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli Kazuhito M, Ferguson AR, Aboubacar W, Youngjae R. Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli. Frontiers in Molecular Neuroscience. Vol. 17. 2024. doi: 10.3389/fnmol.2024.1427070. Abstract Mechanical stimuli, such as stretch, shear stress, or compression, activate a range of biomolecular responses through cellular mechanotransduction. In the nervous system, studies on mechanical stress have highlighted key pathophysiological mechanisms underlying traumatic injury and neurodegenerative diseases. However, the biomolecular pathways triggered by mechanical stimuli in the nervous system has not been fully explored, especially compared to other body systems. This gap in knowledge may be due to the wide variety of methods and definitions used in research. Additionally, as mechanical stimulation techniques such as ultrasound and electromagnetic stimulation are increasingly utilized in psychological and neurorehabilitation treatments, it is vital to understand the underlying biological mechanisms in order to develop accurate pathophysiological models and enhance therapeutic interventions. This review aims to summarize the cellular signaling pathways activated by various mechanical and electromagnetic stimuli with a particular focus on the mammalian nervous system. Furthermore, we briefly discuss potential cellular mechanosensors involved in these processes Open access paper: frontiersin.org neuroscience/articles/10.3389/fnmol.2024.1427070

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typereview

Effect directionunclear

Populationmammalian nervous system

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthInsufficientConfidence: 66% · Peer reviewed: yes

Main findings

Outcomes measured

cellular signaling pathways
cellular mechanotransduction responses
potential cellular mechanosensors

Limitations

No specific electromagnetic exposure parameters (e.g., frequency, intensity/SAR, duration) are provided in the abstract.
The abstract does not describe specific included study designs, populations, or quantitative results.

View raw extracted JSON

{
  "study_type": "review",
  "exposure": {
    "band": null,
    "source": "electromagnetic stimulation",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "mammalian nervous system",
  "sample_size": null,
  "outcomes": [
    "cellular signaling pathways",
    "cellular mechanotransduction responses",
    "potential cellular mechanosensors"
  ],
  "main_findings": "This review summarizes cellular signaling pathways in the mammalian nervous system reported to be activated by various mechanical and electromagnetic stimuli, and briefly discusses potential cellular mechanosensors involved.",
  "effect_direction": "unclear",
  "limitations": [
    "No specific electromagnetic exposure parameters (e.g., frequency, intensity/SAR, duration) are provided in the abstract.",
    "The abstract does not describe specific included study designs, populations, or quantitative results."
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "mechanotransduction",
    "nervous system",
    "mechanical stimuli",
    "electromagnetic stimulation",
    "ultrasound",
    "neurorehabilitation",
    "cellular signaling pathways",
    "mechanosensors"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3389/fnmol.2024.1427070
PubMed: Not supplied

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