A review on the consequences of molecular & genomic alterations following exposure to EMF:
Keywords
The review describes reported associations between EMF exposure and neurological/cognitive changes, including memory and learning changes linked to hippocampal neuronal plasticity and alterations in metabolism and neurotransmitter levels. It also summarizes r…
Study snapshot
Abstract
A review on the consequences of molecular & genomic alterations following exposure to EMF: Remodeling of neuronal network & cognitive changes Abtin S, Seyedaghamiri F, Aalidaeijavadi Z, Farrokhi AM, Moshrefi F, Ziveh T, Zibaii MI, Aliakbarian H, Rezaei-Tavirani M, Haghparast A. A review on the consequences of molecular and genomic alterations following exposure to electromagnetic fields: Remodeling of neuronal network and cognitive changes. Brain Research Bulletin, Volume 217, 2024. doi: 10.1016/j.brainresbull.2024.111090. Abstract The use of electromagnetic fields (EMFs) is essential in daily life. Since 1970, concerns have grown about potential health hazards from EMF. Exposure to EMF can stimulate nerves and affect the central nervous system, leading to neurological and cognitive changes. However, current research results are often vague and contradictory. These effects include changes in memory and learning through changes in neuronal plasticity in the hippocampus, synapses and hippocampal neuritis, and changes in metabolism and neurotransmitter levels. Prenatal exposure to EMFs has negative effects on memory and learning, as well as changes in hippocampal neuron density and histomorphology of hippocampus. EMF exposure also affects the structure and function of glial cells, affecting gate dynamics, ion conduction, membrane concentration, and protein expression. EMF exposure affects gene expression and may change epigenetic regulation through effects on DNA methylation, histone modification, and microRNA biogenesis, and potentially leading to biological changes. Therefore, exposure to EMFs possibly leads to changes in cellular and molecular mechanisms in central nervous system and alter cognitive function. Open access paper: sciencedirect.com
AI evidence extraction
Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.
Main findings
The review describes reported associations between EMF exposure and neurological/cognitive changes, including memory and learning changes linked to hippocampal neuronal plasticity and alterations in metabolism and neurotransmitter levels. It also summarizes reported effects on glial cell structure/function and on gene expression and epigenetic regulation, while noting that current research findings are often vague and contradictory.
Outcomes measured
- neurological changes
- cognitive changes
- memory
- learning
- neuronal plasticity (hippocampus)
- synapses and hippocampal neurites
- metabolism changes
- neurotransmitter level changes
- hippocampal neuron density
- hippocampal histomorphology
- glial cell structure and function
- ion conduction and membrane properties
- protein expression
- gene expression changes
- epigenetic regulation (DNA methylation, histone modification, microRNA biogenesis)
Limitations
- Review notes that current research results are often vague and contradictory.
- No specific EMF type/band, frequency, SAR, or exposure duration is provided in the abstract.
View raw extracted JSON
{
"study_type": "review",
"exposure": {
"band": null,
"source": null,
"frequency_mhz": null,
"sar_wkg": null,
"duration": null
},
"population": null,
"sample_size": null,
"outcomes": [
"neurological changes",
"cognitive changes",
"memory",
"learning",
"neuronal plasticity (hippocampus)",
"synapses and hippocampal neurites",
"metabolism changes",
"neurotransmitter level changes",
"hippocampal neuron density",
"hippocampal histomorphology",
"glial cell structure and function",
"ion conduction and membrane properties",
"protein expression",
"gene expression changes",
"epigenetic regulation (DNA methylation, histone modification, microRNA biogenesis)"
],
"main_findings": "The review describes reported associations between EMF exposure and neurological/cognitive changes, including memory and learning changes linked to hippocampal neuronal plasticity and alterations in metabolism and neurotransmitter levels. It also summarizes reported effects on glial cell structure/function and on gene expression and epigenetic regulation, while noting that current research findings are often vague and contradictory.",
"effect_direction": "mixed",
"limitations": [
"Review notes that current research results are often vague and contradictory.",
"No specific EMF type/band, frequency, SAR, or exposure duration is provided in the abstract."
],
"evidence_strength": "insufficient",
"confidence": 0.74,
"peer_reviewed_likely": "unknown",
"keywords": [
"electromagnetic fields",
"EMF exposure",
"central nervous system",
"neuronal network remodeling",
"cognition",
"memory",
"learning",
"hippocampus",
"neuronal plasticity",
"glial cells",
"gene expression",
"epigenetics",
"DNA methylation",
"histone modification",
"microRNA"
],
"suggested_hubs": []
}AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.
Identifiers and source
DOI: 10.1016/j.brainresbull.2024.111090
PubMed: Not supplied